The nuclear envelope component proline-rich protein 14 (PRR14) is involved in the nuclear morphological alteration and activation of the mTOR (mammalian target of rapamycin) signaling pathway, and has been repeatedly shown to be upregulated in patients with Parkinson’s disease (PD). The aim of this study was to explore whether PRR14 can be used as a potential biomarker for the diagnosis of PD. We compared PRR14 expression in PD patients and normal controls in gene expression omnibus (GEO) data. Quantitative enzyme-linked immunosorbent assay (ELISA) was used to detect PRR14 expression in PD patients and age- and sex-matched controls. The relationship between serum PRR14 and clinical phenotype was evaluated using correlation analysis and logistic regression. The expression of PRR14 in whole blood, substantia nigra, and medial substantia nigra was significantly higher in PD patients than in the healthy control group. Compared to plasma, serum was more suitable for the detection of PRR14. Furthermore, serum PRR14 level in PD patients was significantly higher than that in age- and sex-matched controls. The area under the curve for serum PRR14 level in the ability to identify PD versus age- and sex-matched controls was 0.786. In addition, serum PRR14 level was found to correlate with constipation in PD patients. Our findings demonstrate for the first time that serum PRR14 is a potential biomarker for PD.

核膜成分富含脯氨酸的蛋白 14 (PRR14) 参与核形态的改变和 mTOR（哺乳动物雷帕霉素靶标）信号通路的激活，并且已多次被证明在帕金森病 (PD) 患者中表达上调。本研究的目的是探讨PRR14是否可以作为PD诊断的潜在生物标志物。我们在基因表达综合 (GEO) 数据中比较了 PD 患者和正常对照中 PRR14 的表达。采用定量酶联免疫吸附测定 (ELISA) 检测 PD 患者以及年龄和性别匹配对照中 PRR14 的表达。使用相关分析和逻辑回归评估血清PRR14与临床表型之间的关系。PD患者全血、黑质、内侧黑质中PRR14的表达量显着高于健康对照组。与血浆相比，血清更适合PRR14的检测。此外，PD患者的血清PRR14水平显着高于年龄和性别匹配的对照组。与年龄和性别匹配对照相比，血清 PRR14 水平识别 PD 能力的曲线下面积为 0.786。此外，还发现血清PRR14水平与PD患者的便秘相关。我们的研究结果首次证明血清 PRR14 是 PD 的潜在生物标志物。