A strategy to combine two non-contrast-enhanced magnetic resonance angiography techniques is presented. It is based on arterial spin-labeled magnetic resonance imaging to visualize the arterial system at different time points to obtain information about hemodynamic properties in conjunction with a high-resolution time-of-flight angiography acquisition. The temporal information obtained by arterial spin labeling (ASL) is combined with the highly spatial resolved time-of-flight image to obtain information about blood flow. Extracting the information of ASL and time-of-flight-imaging leads to images with high spatial resolution which also give information about the temporal course of blood through the intracerebral vasculature. Furthermore, owing to the properties of ASL, visible venous flow in the time-of-flight images can be suppressed. The behavior of vascular filling (i.e. signal changes in the ASL) is investigated and used for further interpretation of the data. Furthermore, the ASL data were down-sampled to find a minimally needed spatial resolution to combine both image types. Up to 1.6 mm isotropic resolution still showed satisfying results rated by two independent readers. In conclusion, a combination of these two different vascular imaging modalities allows to obtain highly spatial and time-resolved images.

中文翻译：

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结合动脉自旋标记和飞行时间成像的时间分辨高分辨率血管造影术

提出了一种结合两种非对比增强磁共振血管造影技术的策略。它基于动脉自旋标记的磁共振成像，在不同时间点可视化动脉系统，以获取有关血液动力学特性的信息，并结合高分辨率飞行时间血管造影采集。通过动脉自旋标记 (ASL) 获得的时间信息与高度空间分辨的飞行时间图像相结合，以获得有关血流的信息。提取 ASL 和飞行时间成像的信息会产生具有高空间分辨率的图像，这也提供了关于血液通过脑内脉管系统的时间过程的信息。此外，由于 ASL 的特性，可以抑制飞行时间图像中的可见静脉血流。血管填充的行为（即 ASL 中的信号变化）被研究并用于进一步解释数据。此外，对 ASL 数据进行下采样以找到最低需要的空间分辨率来组合两种图像类型。高达 1.6 mm 的各向同性分辨率仍显示出令人满意的结果，由两个独立的阅读器评定。总之，这两种不同血管成像方式的组合允许获得高度空间和时间分辨的图像。