The faulty hormonal imprinting theory (published in 1980) and the DOHaD (Developmental Origin of Health and Disease theory (published in 1986) are twin-concepts: both justify the manifestation after long time (in adults) diseases which had been provoked in differentiating cells (e.g. during gestation). This was demonstrated using animal experiments as well, as comparative statistical methods (in human cases). However, there is no explanation for the tools of memorization (even after decades) of the early adversity and the tools of execution (manifestation) in adult age. It seems likely that immune memory is involved to the memorization of early adversity, up to the manifestation of the result (non-communicable diseases). Nevertheless, the relatively short timespan of adaptive immune memory makes this system insuitable for this function, however the newly recognized trained memory of the innate immune system seems to be theoretically suitable for the storage of the records and handling the sequalae, which is the epigenetic reprogramming in the time of provocation, without changes in base sequences (mutation). The flawed (damaged) program is manifested later, in adult age. Evidences are incomplete, so further animal experiments and human observations are needed for justifying the theory.

中文翻译：

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训练有素的免疫力在错误的激素印迹和DOHaD中的可能贡献：回顾和假设。

但是，新近公认的先天免疫系统训练后的记忆在理论上似乎适合于记录的存储和处理鳞茎，这是挑衅时的表观遗传重编程，无需改变碱基序列（突变）。有缺陷的（损坏的）程序会在成年后出现。证据不完整，因此需要进一步的动物实验和人类观察来证明该理论是正确的。