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Cellular and molecular mechanisms that regulate mammalian digit tip regeneration
Open Biology ( IF 5.8 ) Pub Date : 2020-09-30 , DOI: 10.1098/rsob.200194
Mekayla A Storer 1 , Freda D Miller 1, 2, 3, 4
Affiliation  

Digit tip regeneration is one of the few examples of true multi-tissue regeneration in an adult mammal. The key step in this process is the formation of the blastema, a transient proliferating cell mass that generates the different cell types of the digit to replicate the original structure. Failure to form the blastema results in a lack of regeneration and has been postulated to be the reason why mammalian limbs cannot regrow following amputation. Understanding how the blastema forms and functions will help us to determine what is required for mammalian regeneration to occur and will provide insights into potential therapies for mammalian tissue regeneration and repair. This review summarizes the cellular and molecular mechanisms that influence murine blastema formation and govern digit tip regeneration.



中文翻译:

调节哺乳动物指尖再生的细胞和分子机制

指尖再生是成年哺乳动物真正多组织再生的少数例子之一。该过程的关键步骤是胚泡的形成,胚泡是一种瞬时增殖的细胞团,可产生不同的手指细胞类型以复制原始结构。未能形成胚泡会导致缺乏再生,并被认为是哺乳动物四肢在截肢后无法再生的原因。了解胚泡的形成和功能将帮助我们确定发生哺乳动物再生所需的条件,并将为哺乳动物组织再生和修复的潜在疗法提供见解。本综述总结了影响小鼠胚泡形成和控制指尖再生的细胞和分子机制。

更新日期:2020-09-30
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