Wound healing is a complex, dynamic process supported by a myriad of cellular events that must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound-linked cellular behaviours, as occurs with diabetes and ageing, can lead to healing impairment and the formation of chronic, non-healing wounds. These wounds are a significant socioeconomic burden due to their high prevalence and recurrence. Thus, there is an urgent requirement for the improved biological and clinical understanding of the mechanisms that underpin wound repair. Here, we review the cellular basis of tissue repair and discuss how current and emerging understanding of wound pathology could inform future development of efficacious wound therapies.

伤口愈合是一个复杂的动态过程，由无数细胞事件支持，必须紧密协调才能有效修复受损组织。与糖尿病和衰老相关的与伤口相关的细胞行为紊乱会导致愈合障碍和慢性非愈合伤口的形成。这些伤口因其高患病率和高复发率而成为重大的社会经济负担。因此，迫切需要提高对伤口修复机制的生物学和临床理解。在这里，我们回顾了组织修复的细胞基础，并讨论了当前和新兴的对伤口病理学的理解如何为有效伤口治疗的未来发展提供信息。