Ten plant extracts were prepared and tested in in vitro assays against COX-2, COX-1 and acetylcholinesterase with evaluation of their antioxidant properties. The tested extracts exhibited varied anti COX-2 effect and they were superior to celecoxibe (inhibition percentage was 42.67% at 50 µg/mL), reference drug. Lavandula coronopifolia and Scrophularia Libanotica extracts were the efficient inhibitors (100% and 91% at 50 µg/mL respectively). Launaeaspinosa and Pulicaria undulata were the powerful AChE inhibitor (IC₅₀ values were 16.69 and 29.06 µg/mL, respectively) followed with L. coronopifolia and S.libanotica extracts (IC₅₀ values were 61.89 and 49.83 µg/mL, respectively) and they were efficient in scavenging superoxide radicals and metal ions, nitric oxide formation inhibition, as well as, lipid peroxide production suppression. L. coronopifolia and S. Libanotica extracts can be introduced as natural cyclooxygenase-2 inhibitors without affecting cyclooxygenase-1 whereas L. spinosa and P. undulata extracts were potent suppressor for AChE with robust antioxidant properties which suggest the possibility of using the four extracts, L. coronopifolia, S. libanotica, L. spinosa and P. undulata as natural agent in treating neurodegenerative disorder.

中文翻译：

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西奈埃及植物提取物的体外抗炎和乙酰胆碱酯酶抑制作用

制备了十种植物提取物，并在体外测定中针对COX-2，COX-1和乙酰胆碱酯酶进行了测试，并评估了它们的抗氧化性能。所测试的提取物表现出不同的抗COX-2效果，并且优于参考药物塞来昔布（在50 µg / mL时抑制率为42.67％）。薰衣草和玄参提取物是有效的抑制剂（50 µg / mL分别为100％和91％）。Launaeaspinosa和蚤草属undulata是强大的乙酰胆碱酯酶抑制剂（IC ₅₀值分别为16.69和29.06微克/毫升，分别），接着用L. coronopifolia和S. libanotica提取物（IC ₅₀值分别为61.89和49.83 µg / mL），它们可有效清除超氧自由基和金属离子，抑制一氧化氮的形成以及抑制脂质过氧化物的产生。L. coronopifolia和S. Libanotica提取物可以被引入作为天然环氧化酶-2抑制剂，而不影响环氧合酶-1而L.刺和P. undulata萃取物有效抑制的AChE为具有强大的抗氧化性能，其建议使用4种提取物的可能性，L. coronopifolia，S. libanotica，L.刺和P. undulata 作为治疗神经退行性疾病的天然药物。