Herbs and spices of natural origin have been used traditionally for culinary and therapeutic purposes. Ursolic acid, a pentacyclic triterpenoid, is a major component of various foods, herbs and spices utilized in daily life. The purpose of this study was to investigate the cardio-protective action of ursolic acid against cardio-toxicity induced by cyclophosphamide. Animals were randomly divided into control group (1% dimethyl sulfoxide, s.c.), toxic control (Cyclophosphamide 200 mg/kg, i.p.), ursolic acid treated (40 mg/kg, s.c.) and ursolic acid-cyclophosphamide combination treatment. Animals were sacrificed at the end of the treatment period and biochemical, electrocardiographic and histopathological changes were measured. Cyclophosphamide treatment showed marked increase in biomarker enzymes (CKNAC, CKMB, LDH, AST, and ALT), decreased tissue antioxidants (SOD, catalase & GSH), hyperlipidemia (TC, TG) and abnormal electrocardiographic (HR, RR, QRS, QT & PR intervals) and histopathological changes. Ursolic acid treatment restored tissue antioxidants, normalised biochemical and electrocardiographic parameters and prevented structural damage of the myocardium. Findings from this study indicate the protective role of ursolic acid against cardiotoxicity caused by cyclophosphamide.

中文翻译：

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熊果酸可预防wistar大鼠环磷酰胺引起的心肌氧化组织损伤

传统上将天然来源的草药和香料用于烹饪和治疗目的。乌索酸是一种五环三萜类化合物，是日常生活中使用的各种食品，草药和香料的主要成分。这项研究的目的是研究熊果酸对环磷酰胺诱导的心脏毒性的心脏保护作用。将动物随机分为对照组（1％二甲基亚砜，皮下注射），毒性对照（环磷酰胺200 mg / kg，腹腔注射），熊果酸处理（40 mg / kg，皮下注射）和熊果酸-环磷酰胺联合治疗。在治疗期结束时处死动物，并测量生化，心电图和组织病理学变化。环磷酰胺处理显示生物标记酶（CKNAC，CKMB，LDH，AST和ALT）显着增加，降低组织抗氧化剂（SOD，过氧化氢酶和GSH），高脂血症（TC，TG）和异常心电图（HR，RR，QRS，QT和PR间隔）和组织病理学改变。熊果酸治疗可恢复组织抗氧化剂，正常化的生化和心电图参数并防止心肌的结构损伤。这项研究的结果表明，熊果酸对环磷酰胺引起的心脏毒性具有保护作用。