Melt electrowriting (MEW) can print high-resolution scaffolds with the ultrafine fibers from 800 nm to 20 µm. However, the cell seeding efficiency relatively low due to the large pore size of the MEW scaffold. Here, we reported a method to solve this dilemma by electrospinning a gelatin methacrylate (GelMA) hydrogel fibers membrane (HFM) on the MEW scaffold. This composite scaffold can own the controlled structures and porosity and excellent cell seeding performance. We systematically investigate the fabrication, morphology, and biocompatibility of composite scaffolds. The implanting of human umbilical vein endothelial cells(HUVES) showed excellent adhesion and biocompatibility on the composite scaffold. Moreover, the cells migrated gradually into the MEW scaffold along the GelMA HFM to form the cell sheet. We hold the opinion that the composite scaffolds have potential applications in the field of tissue engineering repair.

熔体电写 (MEW) 可以使用 800 nm 到 20 µm 的超细纤维打印高分辨率支架。然而，由于 MEW 支架的孔径较大，细胞接种效率相对较低。在这里，我们报告了一种通过在 MEW 支架上静电纺丝甲基丙烯酸明胶 (GelMA) 水凝胶纤维膜 (HFM) 来解决这一困境的方法。这种复合支架具有可控的结构和孔隙率以及优异的细胞接种性能。我们系统地研究了复合支架的制造、形态和生物相容性。人脐静脉内皮细胞（HUVES）的植入在复合支架上显示出优异的粘附性和生物相容性。此外，细胞沿着 GelMA HFM 逐渐迁移到 MEW 支架中，形成细胞片。