With the rapid development of precision medicine industry, DNA sequencing becomes increasingly important as a research and diagnosis tool. For clinical applications, medical professionals require a platform which is fast, easy to use, and presents clear information relevant to definitive diagnosis. We have developed a single molecule desktop sequencing platform, GenoCare 1600. Fast library preparation (without amplification) and simple instrument operation make it friendlier for clinical use. Here we presented sequencing data of E. coli sample from GenoCare 1600 with consensus accuracy reaches 99.99%. We also demonstrated sequencing of microbial mixtures and COVID-19 samples from throat swabs. Our data show accurate quantitation of microbial, sensitive identification of SARS-CoV-2 virus and detection of variants confirmed by Sanger sequencing.

中文翻译：

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GenoCare 1600平台上的两色单分子测序可促进临床应用

随着精密医药行业的飞速发展，DNA测序作为研究和诊断工具变得越来越重要。对于临床应用，医学专业人员需要一个快速，易于使用的平台，并提供与明确诊断有关的清晰信息。我们已经开发了单分子台式测序平台GenoCare1600。快速的文库制备（无需扩增）和简单的仪器操作使其对临床使用更加友好。在这里，我们介绍了来自GenoCare 1600的大肠杆菌样品的测序数据，共识准确性达到99.99％。我们还演示了对微生物混合物和咽拭子中COVID-19样品的测序。我们的数据显示了微生物的准确定量，SARS-CoV-2病毒的灵敏鉴定以及Sanger测序证实的变体检测。