This review focuses on current knowledge of paternal contributions to preimplantation embryonic development with particular emphasis on large animals. Specifically, the included content aims to summarize genomic and epigenomic contributions of paternally expressed genes, their regulation, and chromatin structure that are indispensable for early embryo development. The accumulation of current knowledge will summarize conserved allelic function among species to include functional molecular and genomic studies across large domestic animals in context with reference to founding experimental models.

中文翻译：

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父系对大型动物早期胚胎发育的贡献动态

本综述侧重于父系对胚胎植入前胚胎发育的贡献的当前知识，特别强调大型动物。具体而言，所包含的内容旨在总结父本表达基因的基因组和表观基因组贡献、它们的调控以及早期胚胎发育必不可少的染色质结构。当前知识的积累将总结物种间保守的等位基因功能，包括在参考建立实验模型的背景下对大型家畜的功能分子和基因组研究。