An x-ray phase tomographic microscope has been developed by optimizing the optical system for 9-keV synchrotron x rays at BL37XU, SPring-8, Japan. The system consists of a full-field x-ray imaging microscope and a Talbot interferometer. In contrast with our previous system, a Fresnel zone plate for the microscope objective and transmission gratings of the interferometer was designed to improve the refraction sensitivity, with a larger field of view and a higher spatial resolution, utilizing a 28-m space available at BL37XU. An x-ray phase tomographic microscope with a field of view of 375 µm and a spatial resolution of 560 nm was thus constructed, even with a considerably low x-ray dosage. By applying this tomographic microscope to auditory bone specimens of young mice, it was shown that soft tissues in addition to bone tissue could be observed simultaneously without serious radiation damage.

中文翻译：

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基于Talbot干涉仪的BL37XU，SPring-8的X射线断层扫描显微镜的研制

通过优化日本SPring-8的BL37XU的9-keV同步加速器X射线的光学系统，开发了一种X射线相层析成像显微镜。该系统由一个全视野X射线成像显微镜和一个Talbot干涉仪组成。与我们之前的系统相比，用于显微镜物镜的菲涅耳波带片和干涉仪的透射光栅被设计为利用BL37XU提供的28 m空间来提高折射灵敏度，更大的视野和更高的空间分辨率。 。X射线相层析成像显微镜，视野为375 µ因此，即使具有相当低的X射线剂量，也可以构建560nm的空间分辨率。通过将该断层扫描显微镜应用于年幼小鼠的听觉骨标本，结果表明，除了骨组织外，还可以同时观察到软组织，而不会造成严重的辐射损伤。