Food thickening agents are used to aid the administration of medicine to elderly patients with dysphagia. Magnesium oxide tablets are sometimes administered with food thickening agents. Non-disintegration and disintegration delay of these tablets in the body are problems associated with food thickening agent use. However, the appropriate usage of food thickening agents for administering tablets is not established. Here, the reasons for the non-disintegration of magnesium oxide tablets administered with food thickeners and appropriate usage of food thickeners were examined using a disintegration test of newly opened and moisture-absorbed magnesium oxide tablets. Immersion of magnesium oxide tablets for 10 and 30 min in xanthan and guar gum-based food thickening agents caused disintegration delay and non-disintegration in the first fluid (pH 1.2). However, tablets immersed for 1 min quickly disintegrated. The disintegration of xanthan gum-based food thickening agents was faster than guar gum-based food thickening agents. Moisture absorption by magnesium oxide tablets caused a significant delay in their disintegration in water. The tablets that absorbed moisture disintegrated within 1 min in the first fluid, even when immersed in food thickening agents for a short time. Overall, a short immersion of magnesium oxide tablets in food thickening agents can avoid non-disintegration.

食物增稠剂用于帮助吞咽困难的老年患者给药。氧化镁片剂有时与食物增稠剂一起给药。这些片剂在体内的不崩解和崩解延迟是与食品增稠剂使用相关的问题。然而，用于片剂给药的食品增稠剂的适当用法尚未确定。在这里，使用新开的和吸湿的氧化镁片的崩解试验来检查与食品增稠剂一起给药的氧化镁片不崩解的原因以及食品增稠剂的适当使用。将氧化镁片在黄原胶和瓜尔胶基食品增稠剂中浸泡 10 和 30 分钟，导致在第一次流体 (pH 1.2) 中的崩解延迟和不崩解。然而，浸泡 1 分钟的药片很快就会崩解。黄原胶基食品增稠剂的崩解速度比瓜尔胶基食品增稠剂快。氧化镁片剂的吸湿性导致其在水中崩解的显着延迟。吸收水分的片剂在第一次液体中会在 1 分钟内崩解，即使在短时间内浸入食品增稠剂也是如此。总的来说，将氧化镁片在食品增稠剂中短暂浸泡可以避免不崩解。吸收水分的片剂在第一次液体中会在 1 分钟内崩解，即使在短时间内浸入食品增稠剂也是如此。总的来说，将氧化镁片在食品增稠剂中短暂浸泡可以避免不崩解。吸收水分的片剂在第一次液体中会在 1 分钟内崩解，即使在短时间内浸入食品增稠剂也是如此。总的来说，将氧化镁片在食品增稠剂中短暂浸泡可以避免不崩解。