SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Here, we investigated the interaction of this new coronavirus with Vero cells using high resolution scanning electron microscopy. Surface morphology, the interior of infected cells and the distribution of viral particles in both environments were observed 2 and 48 h after infection. We showed areas of viral processing, details of vacuole contents, and viral interactions with the cell surface. Intercellular connections were also approached, and viral particles were adhered to these extensions suggesting direct cell-to-cell transmission of SARS-CoV-2.

中文翻译：

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通过高分辨率扫描电子显微镜对 SARS-CoV-2 与宿主细胞相互作用的超微结构分析

SARS-CoV-2 是持续发生的 COVID-19 大流行的原因。在这里，我们使用高分辨率扫描电子显微镜研究了这种新型冠状病毒与 Vero 细胞的相互作用。感染后 2 小时和 48 小时观察表面形态、受感染细胞的内部和两种环境中病毒颗粒的分布。我们展示了病毒加工区域、液泡内容的细节以及病毒与细胞表面的相互作用。还研究了细胞间连接，病毒颗粒粘附在这些延伸部分上，表明 SARS-CoV-2 在细胞间直接传播。