FOXA1 is a key pioneer factor in androgen-receptor activity but has been an elusive drug target. A new study shows that inhibition of the associated cofactor LSD1 modifies the methylation state of FOXA1, thus resulting in chromatin dissociation and tumor inhibition, even in models of treatment-resistant prostate cancer.

中文翻译：

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针对前列腺癌中的LSD1和FOXA1

FOXA1是雄激素受体活性的关键先驱因子，但一直是难以捉摸的药物靶标。一项新研究表明，对相关辅因子LSD1的抑制作用会修饰FOXA1的甲基化状态，从而导致染色质解离和肿瘤抑制作用，即使在具有抗药性的前列腺癌模型中也是如此。