Abstract

Purpose

To compare the size of the coagulation (CZ) and periablational (PZ) zones created with two commercially available devices in clinical use for radiofrequency (RFA) and microwave ablation (MWA), respectively.

Methods

Computer models were used to simulate RFA with a 3-cm Cool-tip applicator and MWA with an Amica-Gen applicator. The Arrhenius model was used to compute the damage index (Ω). CZ was considered when Ω > 4.6 (>99% of damaged cells). Regions with 0.6<Ω < 2.1 were considered as the PZ (tissue that has undergone moderate sub-ablative hyperthermia). The ratio of PZ volume to CZ volume (PZ/CZ) was regarded as a measure of performance, since a low value implies achieving a large CZ while keeping the PZ small.

Results

Ten-min RFA (51 W) created smaller periablational zones than 10-min MWA (11.3 cm³ vs. 17.2−22.9 cm³, for 60−100 W MWA, respectively). Prolonging duration from 5 to 10 min increased the PZ in MWA more than in RFA (2.7 cm³ for RFA vs. 8.3−11.9 cm³ for 60−100 W MWA, respectively). PZ/CZ for RFA were relatively high (65−69%), regardless of ablation time, while those for MWA were highly dependent on the duration (increase of up to 25% between 5 and 10 min) and on the applied power (smaller values as power was raised, 102% for 60 W vs. 81% for 100 W, both for 10 min). The lowest PZ/CZ across all settings was 56%, obtained with 100 W-5 min MWA.

Conclusions

Although RFA creates smaller periablational zones than MWA, 100 W-5 min MWA provides the lowest PZ/CZ.

中文翻译：

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射频和微波消融后的消融区多大？基于计算机的两种当前使用的临床设备的比较研究

摘要

目的

为了比较使用两个临床上分别用于射频（RFA）和微波消融（MWA）的市售设备创建的凝血（CZ）和消融（PZ）区的大小。

方法

使用计算机模型来模拟带有3厘米Cool-tip涂抹器的RFA和带有Amica-Gen涂抹器的MWA。使用Arrhenius模型计算损伤指数（Ω）。当Ω  > 4.6（受损电池的> 99％）时考虑CZ 。0.6 < Ω  <2.1的区域被视为PZ（已经历中度亚烧蚀性高温的组织）。PZ体积与CZ体积之比（PZ / CZ）被视为性能的衡量标准，因为低值意味着在保持PZ较小的同时实现大CZ。

结果

10分钟的RFA（51 W）产生的消融区域比10分钟的MWA小（分别为60-100 W MWA的11.3 cm ³对17.2-22.9 cm ³）。将持续时间从5分钟延长到10分钟，使MWA中的PZ增加幅度大于RFA（RFA为2.7 cm ³，而60-100 W MWA为8.3-11.9 cm ³）。无论消融时间如何，RFA的PZ / CZ都相对较高（65-69％），而MWA的PZ / CZ高度取决于持续时间（5至10分钟内最多增加25％）和所施加的功率（较小）功率提高时的最大功率值，60 W时为102％，而100 W时为81％，均为10分钟）所有设置中最低的PZ / CZ为56％，是通过100 W-5分钟的MWA获得的。

结论

尽管RFA产生的消融区比MWA小，但100 W-5分钟的MWA提供最低的PZ / CZ。