ABSTRACT

Autophagy is a cellular housekeeping process that incorporates lysosomal-degradation to maintain cell survival and energy sources. In recent decades, the role of autophagy has implicated in the initiation and development of many diseases that affect humanity. Among these diseases are autoimmune diseases and neurodegenerative diseases, which connected with the lacking autophagy. Other diseases are connected with the increasing levels of autophagy such as cancers and infectious diseases. Therefore, controlling autophagy with sufficient regulators could represent an effective strategy to overcome such diseases. Interestingly, targeting autophagy can also provide a sufficient method to combat the current epidemic caused by the ongoing coronavirus. In this review, we aim to highlight the physiological function of the autophagic process to understand the circumstances surrounding its role in the cellular immunity associated with the development of human diseases.

摘要

自噬是一种细胞管家过程，它结合溶酶体降解来维持细胞存活和能量来源。近几十年来，自噬的作用涉及许多影响人类的疾病的发生和发展。这些疾病包括自身免疫性疾病和神经退行性疾病，它们与缺乏自噬有关。其他疾病与癌症和传染病等自噬水平的提高有关。因此，用足够的调节剂控制自噬可能是克服此类疾病的有效策略。有趣的是，靶向自噬也可以提供一种足够的方法来对抗当前由正在进行的冠状病毒引起的流行病。在本次审查中，