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Understanding the complicated relationship between antioxidants and carcinogenesis
Journal of Biochemical and Molecular Toxicology ( IF 3.6 ) Pub Date : 2020-09-29 , DOI: 10.1002/jbt.22643
Debabrata Majumder 1 , Priyatosh Nath 1 , Rahul Debnath 1 , Debasish Maiti 1
Affiliation  

Reactive oxygen species (ROS) are generated as by‐product of cellular respiration and also due to the exposure of various xenobiotics, whereas mitochondrial electron transport chain is considered as the main source of ROS generation. The sequential addition to molecular oxygen gives rise to various forms of ROS like superoxide anion, peroxide, hydroxyl radical, hydroxyl ion, and so forth. However, the uncontrolled level of ROS generation and accumulation alters the body homeostasis. Excessive generation of ROS leads to oxidative stress and various kinds of diseases including cancer. To counteract ROS, enzymatic and nonenzymatic antioxidants' armory is available in our body. Apart from endogenous antioxidants, we are also consuming various exogenous antioxidants. Antioxidants protect us from ROS‐mediated damages and inhibit ROS‐induced carcinogenesis. Recent studies have revealed that antioxidants could also act as tumor‐promoting agents. Various anticancer drugs are used to kill the cancer cells through the generation of oxidative stress in them, but the cancer cells can counteract the effect with the help of various endogenous as well as exogenous antioxidants. Our review will summarize the multifaceted relationship between antioxidants and carcinogenesis, and it will help to create new directions in antioxidant‐based chemotherapy.

中文翻译:

了解抗氧化剂与致癌作用之间的复杂关系

活性氧(ROS)是细胞呼吸的副产物,也是由于各种异源生物的暴露而产生的,而线粒体电子传输链被认为是ROS产生的主要来源。分子氧的顺序添加会产生各种形式的ROS,例如超氧阴离子,过氧化物,羟基自由基,羟基离子等。但是,ROS产生和积累的水平不受控制,会改变人体的体内平衡。ROS的过量产生导致氧化应激和包括癌症在内的各种疾病。为了抵消ROS,我们体内有酶促和非酶促的抗氧化剂。除了内源性抗氧化剂外,我们还消耗各种外源性抗氧化剂。抗氧化剂保护我们免受ROS介导的损害,并抑制ROS诱导的癌变。最近的研究表明,抗氧化剂也可以充当肿瘤促进剂。各种抗癌药被用来通过在癌细胞中产生氧化应激来杀死癌细胞,但是癌细胞可以借助各种内源性和外源性抗氧化剂来抵消这种作用。我们的综述将总结抗氧化剂与癌变之间的多方面关系,这将有助于在基于抗氧化剂的化学疗法方面开辟新的方向。但是癌细胞可以借助各种内源性和外源性抗氧化剂来抵消这种作用。我们的综述将总结抗氧化剂与癌变之间的多方面关系,这将有助于在基于抗氧化剂的化学疗法方面开辟新的方向。但是癌细胞可以借助各种内源性和外源性抗氧化剂来抵消这种作用。我们的综述将总结抗氧化剂与癌变之间的多方面关系,这将有助于在基于抗氧化剂的化学疗法方面开辟新的方向。
更新日期:2020-09-29
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