Ynamides are electron‐rich heteroatom‐substituted alkynes with C−C triple bond directly tethered to the amide group. Over the past decades, ynamides have proven to be versatile reagents for organic synthesis and have received extensive attention. Compared with the well‐established ionic reactions of ynamides, radical‐based ynamide reactions have been exploited relatively seldom. Herein, radical reactions of ynamides, classified by radical attack at the α‐position and β‐position of ynamides, are reviewed by highlighting the reaction selectivity, scope, mechanism, and applicability. The aim of this review is to provide a comprehensive summarization of these advances, casting light on the further development of ynamide chemistry.

中文翻译：

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Ynamides的自由基反应

Yamides 是富含电子的杂原子取代的炔烃，其 C-C 三键直接与酰胺基团相连。在过去的几十年中，ynamides 已被证明是一种多功能的有机合成试剂，并受到了广泛的关注。与成熟的 ynamides 离子反应相比，基于自由基的 ynamide 反应相对较少被利用。在此，通过突出反应选择性、范围、机理和适用性，综述了 ynamides 的自由基反应，通过对 ynamides 的 α 位和 β 位的自由基攻击进行分类。本综述的目的是对这些进展进行全面总结，为炔酰胺化学的进一步发展提供启示。