N⁶‐methyladenosine (m⁶A) is one of the most common internal modifications in messenger RNA, which is necessary for cell physiological activities. A recent study shows that during mammalian hematopoietic development, loss of m⁶A modification leads to the aberrant production of double‐stranded RNA, which results in the abnormal activation of innate immune response, and ultimately leads to hematopoietic failure. Accordingly, m⁶A modification provide us an attractive direction for us to understand mammalian hematopoietic development and innate immune response.

中文翻译：

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M6A 修饰：保护哺乳动物造血发育的机制

N ⁶ ‐甲基腺苷 (m ⁶ A) 是信使 RNA 中最常见的内部修饰之一，是细胞生理活动所必需的。最近的一项研究表明，在哺乳动物造血发育过程中，m ⁶ A 修饰的缺失导致双链 RNA 的异常产生，从而导致先天免疫反应的异常激活，最终导致造血功能衰竭。因此，m ⁶ A 修饰为我们了解哺乳动物造血发育和先天免疫反应提供了一个有吸引力的方向。