The CNS accommodates a diverse myeloid immune cell compartment that maintains CNS homeostasis in the steady state while contributing to tissue injury during infectious, autoimmune, and neurodegenerative disease conditions. Autophagy and autophagy proteins play fundamental roles in myeloid cell-related immune functions. Many of these processes do not necessarily involve the canonical formation of a double-membrane structure known as the 'autophagosome' and reflect noncanonical functions of the autophagy machinery. Here, we illustrate recent insights, concepts, and outstanding questions regarding how autophagy pathways in myeloid cells contribute to brain health and disease.

中文翻译：

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CNS 髓样细胞免疫功能中的自噬途径

中枢神经系统容纳了多种髓样免疫细胞区室，可将中枢神经系统稳态维持在稳定状态，同时在感染、自身免疫和神经退行性疾病期间导致组织损伤。自噬和自噬蛋白在骨髓细胞相关的免疫功能中发挥着重要作用。许多这些过程不一定涉及称为“自噬体”的双膜结构的典型形成，并反映了自噬机制的非典型功能。在这里，我们阐述了有关骨髓细胞中的自噬途径如何促进大脑健康和疾病的最新见解、概念和突出问题。