Abstract In multi-wavelength lensfree microscopy (MWLM), a laser source is usually replaced with a light-emitting diode for a low-cost and portable configuration. However, the trade-off between noise suppression and resolution enhancement puts a challenging issue for high-quality imaging. Here we propose a noise-robust multi-wavelength phase retrieval to increase the stability of MWLM. To solve the inverse problem of phase retrieval, we derive an optimization procedure to iteratively minimize the data fidelity and impose a total variation term for noise suppression. The experimental results of resolution target, stained human goblet cell, and label-free microglia cell demonstrate that our method could hold a better noise tolerance without the loss of imaging resolution. We believe that our method will become a powerful tool for a resources-limited scene.

中文翻译：

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基于非线性优化的高质量多波长无透镜显微镜

摘要 在多波长无透镜显微镜 (MWLM) 中，激光源通常被替换为发光二极管，以实现低成本和便携的配置。然而，噪声抑制和分辨率增强之间的权衡为高质量成像带来了挑战。在这里，我们提出了一种抗噪声多波长相位检索，以提高 MWLM 的稳定性。为了解决相位检索的逆问题，我们导出了一个优化程序来迭代地最小化数据保真度，并为噪声抑制施加一个总变化项。分辨率目标、染色的人类杯状细胞和无标记小胶质细胞的实验结果表明，我们的方法可以在不损失成像分辨率的情况下保持更好的噪声耐受性。