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Neural synchronization between the anterior cingulate and orbitofrontal cortices during effort-based decision making
Neurobiology of Learning and Memory ( IF 2.7 ) Pub Date : 2020-09-30 , DOI: 10.1016/j.nlm.2020.107320
Zahra Fatahi 1 , Ahmad Ghorbani 2 , Mohammad Ismail Zibaii 2 , Abbas Haghparast 1
Affiliation  

Optimal decision making reflects the ability to choose the most advantageous option for various alternatives so that the anterior cingulate cortex is an important area involved in effort-based decision making. The current study aimed to investigate the functional connectivity between the ACC (anterior cingulate cortex) and the orbitofrontal cortex (OFC) during effort-based decision-making. A T-maze decision-making task with different rewards (large vs. small reward) and costs (high vs. low effort) was used, and simultaneously, local field potentials (LFP) from the ACC and OFC were also recorded in male Wistar rats. During the effort-based decision making, when the animals preferred the higher over, the lower reward, neural synchronization was observed in theta/low beta (4–20 Hz) frequency bands between both of the areas. Also, neural synchronization was not significant when the animals chose a lower reward. High gamma (80–100 Hz) synchrony between the areas was also observed; however, it was not dependent on the animal's decision. In this regard, the present findings revealed that neural synchronization and functional connectivity between the ACC and OFC in the low-frequency range (theta/low beta) is essential during the effort-based decision making.



中文翻译:

基于努力的决策过程中前扣带回和眶额皮质之间的神经同步

最佳决策反映了为各种替代方案选择最有利选项的能力,因此前扣带皮层是参与基于努力的决策的重要区域。目前的研究旨在调查在基于努力的决策过程中 ACC(前扣带回皮层)和眶额皮层(OFC)之间的功能连接。使用具有不同奖励(大奖励与小奖励)和成本(高与低努力)的 T 迷宫决策任务,同时,来自 ACC 和 OFC 的局部场电位(LFP)也被记录在男性 Wistar 中老鼠。在基于努力的决策过程中,当动物更喜欢更高的奖励时,在两个区域之间的 theta/低 beta (4-20 Hz) 频带中观察到神经同步。还,当动物选择较低的奖励时,神经同步并不显着。还观察到区域之间的高伽马 (80-100 Hz) 同步;然而,这并不取决于动物的决定。在这方面,目前的研究结果表明,在基于努力的决策过程中,低频范围(theta/low beta)中 ACC 和 OFC 之间的神经同步和功能连接是必不可少的。

更新日期:2020-10-12
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