Cytokine storm is a form of uncontrolled systemic inflammatory reaction activated by a variety of factors and leading to a harmful homeostatic process, even to patient’s death. Triggers that start the reaction are infection, systemic diseases and rarely anaphylaxis. Cytokine storm is frequently mentioned in connection to medical interventions such as transplantation or administration of drugs.

Presented mini-review would like to show current possibilities how to fight or even stop such a life-threatening, immune-mediated process in order to save lives, not only in COVID-19 patients.

Early identification of rising state and multilevel course of treatment is imperative. The most widely used molecule for systemic treatment remains tocilizumab. Except for anti IL-6 treatment, contemporary research opens the possibilities for combination of pharmaceutical, non-pharmaceutical and adjunctive treatment in a successful fight with consequences of cytokine storm.

Further work is needed to discover the exact signaling pathways that lead to cytokine storm and to determine how these effector molecules and/or combination of processes can help to resolve this frequently fatal episode of inflammation. It is a huge need for all scientists and clinicians to establish a physiological rational for new therapeutic targets that might lead to more personalized medicine approaches.

细胞因子风暴是一种不受控制的全身炎症反应，由多种因素激活并导致有害的稳态过程，甚至导致患者死亡。引发该反应的诱因是感染、全身性疾病和罕见的过敏反应。细胞因子风暴经常被提及与医学干预有关，例如移植或药物管理。

提出的迷你评论希望展示当前的可能性，即如何对抗甚至停止这种危及生命的免疫介导过程以挽救生命，而不仅仅是在 COVID-19 患者中。

早期识别上升状态和多层次治疗过程势在必行。用于全身治疗的最广泛使用的分子仍然是托珠单抗。除了抗 IL-6 治疗外，当代研究开辟了药物、非药物和辅助治疗相结合以成功应对细胞因子风暴后果的可能性。

需要进一步的工作来发现导致细胞因子风暴的确切信号通路，并确定这些效应分子和/或过程的组合如何帮助解决这种经常致命的炎症发作。所有科学家和临床医生都迫切需要为可能导致更个性化的医学方法的新治疗目标建立生理学理性。