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Creatine metabolism in the uterus: potential implications for reproductive biology
Amino Acids ( IF 3.5 ) Pub Date : 2020-09-29 , DOI: 10.1007/s00726-020-02896-3
Mamatha Philip 1 , Rodney J Snow 1 , Paul A Della Gatta 1 , Nadia Bellofiore 2, 3 , Stacey J Ellery 2, 3
Affiliation  

Creatine is an amino acid derivative synthesized from arginine, glycine and methionine. It serves as the substrate for the creatine kinase system, which is vital for maintaining ATP levels in tissues with high and fluctuating energy demand. There exists evidence that the creatine kinase system operates in both the endometrial and myometrial layers of the uterus. While use and regulation of this system in the uterus are not well understood, it is likely to be important given uterine tissues undergo phases of increased energy demand during certain stages of the female reproductive cycle, pregnancy, and parturition. This review discusses known adaptations of creatine metabolism in the uterus during the reproductive cycle (both estrous and menstrual), pregnancy and parturition, highlighting possible links to fertility and the existing knowledge gaps. Specifically, we discuss the adaptations and regulation of uterine creatine metabolite levels, cell creatine transport, de novo creatine synthesis, and creatine kinase expression in the various layers and cell types of the uterus. Finally, we discuss the effects of dietary creatine on uterine metabolism. In summary, there is growing evidence that creatine metabolism is up-regulated in uterine tissues during phases where energy demand is increased. While it remains unclear how important these adaptations are in the maintenance of healthy uterine function, furthering our understanding of uterine creatine metabolism may uncover strategies to combat poor embryo implantation and failure to conceive, as well as enhancing uterine contractile performance during labor.



中文翻译:

子宫中的肌酸代谢:对生殖生物学的潜在影响

肌酸是由精氨酸,甘氨酸和蛋氨酸合成的氨基酸衍生物。它是肌酸激酶系统的底物,对于维持能量需求高且波动的组织中的ATP水平至关重要。有证据表明肌酸激酶系统在子宫的子宫内膜和子宫肌层均起作用。尽管对该系统在子宫中的使用和调节尚不十分了解,但考虑到子宫组织在女性生殖周期,怀孕和分娩的某些阶段经历能量需求增加的阶段,这可能很重要。这篇综述讨论了生殖周期(发情和月经),妊娠和分娩期间子宫肌酸代谢的已知适应性,强调了与生育力和现有知识鸿沟的可能联系。具体来说,我们讨论子宫肌酸代谢产物水平,细胞肌酸转运,从头肌酸合成以及子宫肌层和细胞类型中肌酸激酶表达的适应和调节。最后,我们讨论饮食肌酸对子宫代谢的影响。总而言之,越来越多的证据表明,在能量需求增加的阶段,子宫组织中的肌酸代谢被上调。虽然尚不清楚这些适应对维持健康的子宫功能有多重要,但加深我们对子宫肌酸代谢的了解,可能会发现对抗不良胚胎着床和无法怀孕以及增强分娩过程中子宫收缩性能的策略。我们讨论了子宫肌酸代谢产物水平,细胞肌酸转运,从头肌酸合成以及子宫肌层和细胞类型中肌酸激酶表达的适应和调节。最后,我们讨论饮食肌酸对子宫代谢的影响。总而言之,越来越多的证据表明,在能量需求增加的阶段,子宫组织中的肌酸代谢被上调。虽然尚不清楚这些适应对维持健康的子宫功能有多重要,但加深我们对子宫肌酸代谢的了解,可能会发现对抗不良胚胎着床和无法怀孕以及增强分娩过程中子宫收缩性能的策略。我们讨论了子宫肌酸代谢产物水平,细胞肌酸转运,从头肌酸合成以及子宫肌层和细胞类型中肌酸激酶表达的适应和调节。最后,我们讨论饮食肌酸对子宫代谢的影响。总而言之,越来越多的证据表明,在能量需求增加的阶段,子宫组织中的肌酸代谢被上调。虽然尚不清楚这些适应对维持健康的子宫功能有多重要,但加深我们对子宫肌酸代谢的了解,可能会发现对抗不良胚胎着床和无法怀孕以及增强分娩过程中子宫收缩性能的策略。和肌酸激酶在子宫各个层和细胞类型中的表达。最后,我们讨论饮食肌酸对子宫代谢的影响。总而言之,越来越多的证据表明,在能量需求增加的阶段,子宫组织中的肌酸代谢被上调。虽然尚不清楚这些适应对维持健康的子宫功能有多重要,但加深我们对子宫肌酸代谢的了解,可能会发现对抗不良胚胎着床和无法怀孕以及增强分娩过程中子宫收缩性能的策略。和肌酸激酶在子宫各个层和细胞类型中的表达。最后,我们讨论饮食肌酸对子宫代谢的影响。总而言之,越来越多的证据表明,在能量需求增加的阶段,子宫组织中的肌酸代谢被上调。虽然尚不清楚这些适应对维持健康的子宫功能有多重要,但加深我们对子宫肌酸代谢的了解,可能会发现对抗不良胚胎着床和无法怀孕以及增强分娩过程中子宫收缩性能的策略。越来越多的证据表明,在能量需求增加的阶段,子宫组织中的肌酸代谢被上调。虽然尚不清楚这些适应对维持健康的子宫功能有多重要,但加深我们对子宫肌酸代谢的了解,可能会发现对抗不良胚胎着床和无法怀孕以及增强分娩过程中子宫收缩性能的策略。越来越多的证据表明,在能量需求增加的阶段,子宫组织中的肌酸代谢会上调。虽然尚不清楚这些适应对维持健康的子宫功能有多重要,但加深我们对子宫肌酸代谢的了解,可能会发现对抗不良胚胎着床和无法怀孕以及增强分娩过程中子宫收缩性能的策略。

更新日期:2020-09-30
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