The relationships between apolipoprotein A-I (APOA-I), apolipoprotein B (APOB) with insulin resistance, metabolic syndrome (MetS) are unclear in OSA. We aimed to evaluate whether the multiple single nucleotide polymorphism (SNP) variants of APOA-I and APOB exert a collaborative effect on insulin resistance and MetS in OSA. Initially, 12 APOA-I SNPs and 30 APOB SNPs in 5259 subjects were examined. After strict screening, four APOA-I SNPs and five APOB SNPs in 4007 participants were included. For each participant, the genetic risk score (GRS) was calculated based on the cumulative effect of multiple genetic variants of APOA-I and APOB. Logistic regression analyses were used to evaluate the relationships between APOA-I/APOB genetic polymorphisms, insulin resistance, and MetS in OSA. Serum APOB levels increased the risk of insulin resistance and MetS adjusting for age, gender and BMI [odds ratio (OR = 3.168, P < 0.001; OR = 6.098, P < 0.001, respectively]. APOA-I GRS decreased the risk of insulin resistance and MetS after adjustments (OR = 0.917, P = 0.001; OR = 0.870, P < 0.001, respectively). APOB GRS had no association with insulin resistance (OR = 1.364, P = 0.610), and had weak association with MetS after adjustments (OR = 1.072, P = 0.042). In addition, individuals in the top quintile of the APOA-I genetic score distribution had a lower risk of insulin resistance and MetS after adjustments (OR = 0.761, P = 0.007; OR = 0.637, P < 0.001, respectively). In patients with OSA, cumulative effects of APOA-I genetic variations decreased the risk of insulin resistance and MetS, whereas multiple APOB genetic variations had no associations with insulin resistance and weak association with MetS.

中文翻译：

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多种载脂蛋白AI和B基因变异对阻塞性睡眠呼吸暂停胰岛素抵抗和代谢综合征的影响

在 OSA 中，载脂蛋白 AI (APOA-I)、载脂蛋白 B (APOB) 与胰岛素抵抗、代谢综合征 (MetS) 之间的关系尚不清楚。我们旨在评估 APOA-I 和 APOB 的多个单核苷酸多态性 (SNP) 变体是否对 OSA 中的胰岛素抵抗和 MetS 发挥协同作用。最初，检查了 5259 名受试者的 12 个 APOA-I SNP 和 30 个 APOB SNP。经过严格筛选，共纳入4007名参与者的4个APOA-I SNP和5个APOB SNP。对于每个参与者，遗传风险评分 (GRS) 是根据 APOA-I 和 APOB 的多个遗传变异的累积效应计算的。逻辑回归分析用于评估 OSA 中 APOA-I/APOB 基因多态性、胰岛素抵抗和 MetS 之间的关系。