Abstract Oxidative stress is a causative factor in the pathophysiology of numerous diseases, such as diabetes, atherosclerosis, cancer, and neurodegenerative and cardiovascular diseases. Therapeutic antioxidants are promising candidates for preventing and treating conditions in which oxidative stress is a contributing factor. In this study, we report the design, synthesis and antioxidant activity of six compounds containing the 2-methoxyphenol moiety core structure. The synthesized derivatives were characterized using 1H NMR, 13C NMR, Fourier-transform infrared (FT-IR), and elemental analysis spectroscopy. The antioxidant properties of the compounds were evaluated using the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and oxygen radical absorbance capacity (ORAC) assay. New phenolic acid-derived compounds with antioxidant activity were identified.

中文翻译：

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一些 2-甲氧基苯酚衍生物的合成、表征和抗氧化活性

摘要 氧化应激是糖尿病、动脉粥样硬化、癌症、神经退行性疾病和心血管疾病等多种疾病病理生理学的致病因素。治疗性抗氧化剂是预防和治疗氧化应激是一个促成因素的疾病的有希望的候选者。在这项研究中，我们报告了六种含有 2-甲氧基苯酚部分核心结构的化合物的设计、合成和抗氧化活性。合成的衍生物使用 1H NMR、13C NMR、傅里叶变换红外 (FT-IR) 和元素分析光谱进行表征。使用 2,2-二苯基-1-苦基-肼基-水合物 (DPPH)、2,2'-叠氮基-双(3-乙基苯并噻唑啉-6-磺酸 (ABTS) 和氧自由基吸收能力（ORAC）测定。