Abstract

The synergistic effects of the combination of hyperthermia and chemotherapy have implicated the critical role of hyperthermia temperatures in clinical practice. Temperature sensitive polymers, which are capable of exhibiting controllable shapes under various temperature actuations, have attracted considerable interests for designing intelligent medical devices. While shape memory performances have been demonstrated with a wide range of temperatures, here we focus our discussion on shape memory polymers with physiologically relevant application temperatures and proper shape recovery speed. This review presents an overview of body-friendly thermo-responsive shape memory polymers, including commonly used biopolymers, various actuation methods, and their potential biomedical applications.

摘要

热疗和化学疗法的组合的协同作用已经暗示了热疗温度在临床实践中的关键作用。在各种温度驱动下能够显示可控形状的温度敏感聚合物，对于设计智能医疗设备引起了相当大的兴趣。虽然已经在很宽的温度范围内证明了形状记忆性能，但在这里我们将重点讨论具有生理相关应用温度和适当形状恢复速度的形状记忆聚合物。这篇综述概述了对人体友好的热响应形状记忆聚合物，包括常用的生物聚合物，各种驱动方法及其潜在的生物医学应用。