Mouse embryonic stem cell (mESC) culture contains various heterogeneous populations, which serve as excellent models to study gene regulation in early embryo development. The heterogeneity is typically defined by transcriptional activities, for example, the expression of Nanog or Rex1 mRNA. Our objectives were to identify mESC heterogeneity that are caused by mechanisms other than transcriptional control.

中文翻译：

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KLF3促进多能干细胞中的8细胞样转录状态

小鼠胚胎干细胞 (mESC) 培养物包含各种异质种群，可作为研究早期胚胎发育中基因调控的优秀模型。异质性通常由转录活动定义，例如 Nanog 或 Rex1 mRNA 的表达。我们的目标是确定由转录控制以外的机制引起的 mESC 异质性。