Recent studies have shown that G protein‐coupled receptors (GPCRs), the largest signal‐conveying receptor family, are targets for mutations occurring frequently in different cancer types. GPCR alterations associated with cancer development represent significant challenges for the discovery and the advancement of targeted therapeutics. Among the different molecules that can activate GPCRs, we focused on two molecules that exert their biological actions regulating many typical features of tumorigenesis such as cellular proliferation, survival, and invasion: somatostatin and melatonin. The modulation of signaling pathways, that involves these two molecules, opens an interesting scenario for cancer therapy, with the opportunity to act at different molecular levels. Therefore, the aim of this review is the analysis of the biological activity and the therapeutic potential of somatostatin and melatonin, displaying a high affinity for GPCRs, that interfere with cancer development and maintenance.

中文翻译：

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两种神经内分泌 G 蛋白偶联受体分子，生长抑素和褪黑激素：信号转导的生理学和治疗前景

最近的研究表明，最大的信号传递受体家族 G 蛋白偶联受体 (GPCR) 是不同癌症类型中频繁发生的突变的靶标。与癌症发展相关的 GPCR 改变对靶向治疗的发现和发展提出了重大挑战。在可以激活 GPCR 的不同分子中，我们关注两种发挥生物学作用的分子，它们可以调节肿瘤发生的许多典型特征，如细胞增殖、存活和侵袭：生长抑素和褪黑激素。涉及这两种分子的信号通路的调节为癌症治疗开辟了一个有趣的场景，有机会在不同的分子水平上发挥作用。所以，