Research question

Does SARS-CoV-2 infection have an effect on ovarian reserve, sex hormones and menstruation of women of child-bearing age?

Design

This is a retrospective, cross-sectional study in which clinical and laboratory data from 237 women of child-bearing age diagnosed with COVID-19 were retrospectively reviewed. Menstrual data from 177 patients were analysed. Blood samples from the early follicular phase were tested for sex hormones and anti-Müllerian hormone (AMH).

Results

Among 237 patients with confirmed COVID-19, severely ill patients had more comorbidities than mildly ill patients (34% versus 8%), particularly for patients with diabetes, hepatic disease and malignant tumours. Of 177 patients with menstrual records, 45 (25%) patients presented with menstrual volume changes, and 50 (28%) patients had menstrual cycle changes, mainly a decreased volume (20%) and a prolonged cycle (19%). The average sex hormone and AMH concentrations of women of child-bearing age with COVID-19 were not different from those of age-matched controls.

Conclusions

Average sex hormone concentrations and ovarian reserve did not change significantly in COVID-19 women of child-bearing age. Nearly one-fifth of patients exhibited a menstrual volume decrease or cycle prolongation. The menstruation changes of these patients might be the consequence of transient sex hormone changes caused by suppression of ovarian function that quickly resume after recovery.

中文翻译：

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COVID-19育龄妇女性激素与月经分析

研究问题

SARS-CoV-2感染对育龄妇女的卵巢储备、性激素和月经有影响吗？

设计

这是一项回顾性横断面研究，其中对 237 名诊断为 COVID-19 的育龄妇女的临床和实验室数据进行了回顾性审查。分析了 177 名患者的月经数据。对来自早期卵泡期的血液样本进行性激素和抗苗勒管激素 (AMH) 测试。

结果

在 237 名确诊的 COVID-19 患者中，重症患者的合并症多于轻症患者（34% 对 8%），尤其是糖尿病、肝病和恶性肿瘤患者。在有月经记录的177例患者中，45例（25%）出现月经量变化，50例（28%）出现月经周期变化，主要是量减少（20%）和周期延长（19%）。患有 COVID-19 的育龄妇女的平均性激素和 AMH 浓度与年龄匹配的对照组没有区别。

结论

COVID-19 育龄妇女的平均性激素浓度和卵巢储备没有显着变化。近五分之一的患者表现出月经量减少或周期延长。这些患者的月经变化可能是卵巢功能受抑制引起的短暂性激素变化，恢复后迅速恢复的结果。