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Neonatal white matter tract microstructure and 2-year language outcomes after preterm birth
NeuroImage: Clinical ( IF 4.2 ) Pub Date : 2020-09-29 , DOI: 10.1016/j.nicl.2020.102446
Sarah E Dubner 1 , Jessica Rose 2 , Lisa Bruckert 1 , Heidi M Feldman 1 , Katherine E Travis 1
Affiliation  

Aim

To determine whether variability in diffusion MRI (dMRI) white matter tract metrics, obtained in a cohort of preterm infants prior to neonatal hospital discharge, would be associated with language outcomes at age 2 years, after consideration of age at scan and number of major neonatal complications.

Method

30 children, gestational age 28.9 (2.4) weeks, underwent dMRI at mean post menstrual age 36.4 (1.4) weeks and language assessment with the Bayley Scales of Infant Development–III at mean age 22.2 (1.7) months chronological age. Mean fractional anisotropy (FA) and mean diffusivity (MD) were calculated for 5 white matter tracts. Hierarchical linear regression assessed associations between tract FA, moderating variables, and language outcomes.

Results

FA of the left inferior longitudinal fasciculus accounted for 17% (p = 0.03) of the variance in composite language and FA of the posterior corpus callosum accounted for 19% (p = 0.02) of the variance in composite language, beyond that accounted for by post-menstrual age at scan and neonatal medical complications. The number of neonatal medical complications moderated the relationship between language and posterior corpus callosum FA but did not moderate the association in the other tract.

Conclusion

Language at age 2 is associated with white matter metrics in early infancy in preterm children. The different pattern of associations by fiber group may relate to the stage of brain maturation and/or the nature and timing of medical complications related to preterm birth. Future studies should replicate these findings with a larger sample size to assure reliability of the findings.



中文翻译:

早产后新生儿白质束微观结构和 2 年语言结果

目的

在考虑扫描年龄和主要新生儿数量后,确定在新生儿出院前一组早产儿中获得的弥散 MRI (dMRI) 白质束指标的变异性是否与 2 岁时的语言结果相关并发症。

方法

30个孩子,胎龄28.9(2.4) 周,在平均月经后年龄 36.4 岁时接受了 dMRI(1.4) 在平均年龄 22.2 (1.7) 个月实足年龄时使用 Bayley 婴儿发展量表 III 进行周数和语言评估。计算 5 个白质束的平均分数各向异性 (FA) 和平均扩散率 (MD)。分层线性回归评估了 tract FA、调节变量和语言结果之间的关联。

结果

左下纵束的 FA 占复合语言方差的 17% (p = 0.03),胼胝体后部的 FA 占复合语言方差的 19% (p = 0.02),超过扫描时的月经后年龄和新生儿医疗并发症。新生儿医学并发症的数量缓和了语言和胼胝体后部 FA 之间的关系,但没有缓和其他区域的关联。

结论

2 岁时的语言与早产儿婴儿早期的白质指标相关。纤维组的不同关联模式可能与大脑成熟阶段和/或早产相关医学并发症的性质和时间有关。未来的研究应该用更大的样本量来复制这些发现,以确保结果的可靠性。

更新日期:2020-10-06
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