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Investigating the role of phase-synchrony during encoding of episodic memories using electrical stimulation
Cortex ( IF 3.6 ) Pub Date : 2020-09-29 , DOI: 10.1016/j.cortex.2020.09.006
Mircea van der Plas 1 , Danying Wang 1 , John-Stuart Brittain 2 , Simon Hanslmayr 1
Affiliation  

The multi-sensory nature of episodic memories indicates that communication between a multitude of brain areas is required for their effective creation and recollection. Previous studies have suggested that the effectiveness of memory processes depends on theta synchronization (4 Hz) of sensory areas relevant to the memory. This study aimed to manipulate theta synchronization between different sensory areas in order to further test this hypothesis. We intend to entrain visual cortex with 4 Hz alternating current stimulation (tACS), while simultaneously entraining auditory cortex with 4 Hz amplitude-modulated sounds. By entraining these different sensory areas, which pertain to learned audio–visual memory associations, we expect to find that when theta is synchronized across the different sensory areas, the memory performance would be enhanced compared to when theta is not synchronized across the sensory areas. We found no evidence for such an effect in this study. It is unclear whether this is due to an inability of 4 Hz tACS to entrain the visual cortex reliably, or whether sensory entrainment is not the underlying mechanism required for episodic memory.



中文翻译:

研究在使用电刺激的情景记忆编码过程中相位同步的作用

情节性记忆的多感官性质表明,多个大脑区域之间的交流是其有效创建和记忆所必需的。先前的研究表明,记忆过程的有效性取决于与记忆有关的感觉区域的θ同步(4 Hz)。这项研究旨在操纵不同感觉区域之间的θ同步,以进一步检验该假设。我们打算用4 Hz交流电刺激(tACS)来夹带视觉皮层,同时用4 Hz调幅声音来夹带听觉皮层。通过训练与学习的视听记忆关联有关的这些不同的感觉区域,我们期望发现当theta在不同的感觉区域之间同步时,与θ在整个感官区域未同步时相比,内存性能将得到提高。在这项研究中,我们没有发现这种作用的证据。尚不清楚这是否是由于4 Hz tACS无法可靠地夹带视觉皮层,还是由于感觉夹带不是情节记忆所需的基本机制。

更新日期:2020-10-30
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