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The Influence of Cannabis and Nicotine Co-Use on Neuromaturation – A Systematic Review of Adolescent and Young Adult Studies
Biological Psychiatry ( IF 10.6 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.biopsych.2020.09.021
Margie Hernandez Mejia 1 , Natasha E Wade 2 , Rachel Baca 2 , Vanessa G Diaz 2 , Joanna Jacobus 2
Affiliation  

Accumulating evidence suggests that the use of cannabis and nicotine and tobacco-related products (NTPs) during the adolescent years has harmful effects on the developing brain. Yet, few studies have focused on the developing brain as it relates to the co-administration of cannabis and NTPs, despite the high prevalence rates of co-use in adolescence. This review aims to synthesize the existing literature on neurocognitive, structural neuroimaging, and functional neuroimaging outcomes associated with cannabis and NTP co-use. A systematic search of peer-reviewed articles resulted in a pool of 1107 articles. Inclusion criteria were 1) data-based study; 2) age range of 13 to 35 years or, for preclinical studies, nonadult subjects; 3) cannabis and NTP group jointly considered; and 4) neurocognitive, structural neuroimaging, or functional neuroimaging as an outcome measure. Twelve studies met inclusion criteria. Consistent with the literature, cannabis and nicotine were found to have independent effects on cognition. The available research on the co-use of cannabis and NTPs demonstrates a potential nicotine-related masking effect on cognitive deficits associated with cannabis use, yet there is little research on co-use and associations with neuroimaging indices. In neuroimaging studies, there is preliminary evidence for hippocampal volume differences in co-users and a lack of evidence for co-use differences related to nucleus accumbens activity during reward processing. Notably, no structural neuroimaging studies were found to examine the combined effects of nicotine and cannabis in adolescent-only populations. Further research, including longitudinal studies, is warranted to investigate the influence of cannabis and NTP co-use on maturation.

中文翻译:

大麻和尼古丁共同使用对神经成熟的影响——青少年和青年研究的系统评价

越来越多的证据表明,在青少年时期使用大麻和尼古丁及烟草相关产品 (NTPs) 会对发育中的大脑产生有害影响。然而,很少有研究关注发育中的大脑,因为它与大麻和 NTP 的共同给药有关,尽管在青春期共同使用的流行率很高。本综述旨在综合现有关于与大麻和 NTP 共同使用相关的神经认知、结构神经影像学和功能性神经影像学结果的文献。对同行评审文章的系统搜索产生了 1107 篇文章。纳入标准为 1) 基于数据的研究;2) 13 至 35 岁的年龄范围,或者,对于临床前研究,非成人受试者;3)大麻和NTP组共同考虑;4) 神经认知、结构神经影像学,或功能性神经影像学作为结果测量。十二项研究符合纳入标准。与文献一致,发现大麻和尼古丁对认知有独立影响。关于大麻和 NTP 共同使用的现有研究表明,尼古丁对与大麻使用相关的认知缺陷具有潜在的掩蔽作用,但关于共同使用和与神经影像学指标的关联的研究很少。在神经影像学研究中,有初步证据表明共同使用者的海马体积差异,但缺乏证据表明在奖励处理过程中与伏隔核活动相关的共同使用差异。值得注意的是,没有发现结构性神经影像学研究来检查尼古丁和大麻对仅青少年人群的综合影响。进一步的研究,包括纵向研究,
更新日期:2021-01-01
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