The feasibility of using molecular genetic markers associated with thyroid neoplasms and more aggressive course of the disease is now actively studied. We analyzed the diagnostic value of somatic mutations in the hot spots of BRAF, KRAS, KRAS, EIF1AX, and TERT genes in histological material from 153 patients with thyroid gland neoplasms. BRAF mutations (exon 15, codon area 600-601) were found in 54 patients, NRAS mutations (exon 3, codon 61) were detected in 12 patients; mutations KRAS, TERT, and EIF1AX genes were not detected.

中文翻译：

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BRAF、KRAS、NRAS、EIF1AX 和 TERT 基因的体细胞突变：甲状腺肿瘤的诊断价值

现在正在积极研究使用与甲状腺肿瘤和更具侵袭性的疾病过程相关的分子遗传标记的可行性。我们分析了 153 名甲状腺肿瘤患者的组织学材料中 BRAF、KRAS、KRAS、EIF1AX 和 TERT 基因热点的体细胞突变的诊断价值。54例患者发现BRAF突变（外显子15，密码子区域600-601），12例患者检测到NRAS突变（外显子3，密码子61）；未检测到 KRAS、TERT 和 EIF1AX 基因突变。