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Effect of α2-Adrenergic Receptor Stimulation on the Isolated Rat Heart against the Background of If Blockade
Bulletin of Experimental Biology and Medicine ( IF 0.7 ) Pub Date : 2020-09-01 , DOI: 10.1007/s10517-020-04943-1
N I Ziyatdinova 1 , A M Kuptsova 1 , M I Sungatullina 1 , T L Zefirov 1
Affiliation  

The study examined the effect of α2-adrenoreceptor (α2-AR) activation against the background of preliminary blockage of If on the performance of Langerndorff-isolated rat heart. Stimulation of α2-AR in isolated rat hearts against the background of ZD7288 in concentrations of 10-9 M and 3×10-5 M changed the negative dynamics of myocardial inotropy to positive (by 25 and 38%; p<0.05). Activation of α2-AR produced opposite effects on HR. If blockade abolished tachycardia caused by activation of α2-AR; HR deceleration in response to α2-AR agonist against the background of If blocker in a concentration 10-9 M was 41% (p<0.05). We observed negative dynamics of coronary flow (by 38%; p<0.05) in isolated adult rat hearts after application of α2-AR agonist against the background of If blockade (10-9 M).

中文翻译:

α2-肾上腺素能受体刺激对 If 阻断背景下离体大鼠心脏的影响

该研究检查了 α2-肾上腺素能受体 (α2-AR) 激活在 If 初步阻断的背景下对 Langerndorff 分离的大鼠心脏性能的影响。在 10-9 M 和 3×10-5 M 浓度的 ZD7288 背景下,在离体大鼠心脏中刺激 α2-AR 将心肌收缩力的负动力学改变为正(分别为 25% 和 38%;p<0.05)。α2-AR 的激活对 HR 产生相反的影响。如果阻断消除了由 α2-AR 激活引起的心动过速;在浓度为 10-9 M 的 If 阻滞剂的背景下,响应 α2-AR 激动剂的 HR 减速为 41% (p<0.05)。我们在 If 阻断 (10-9 M) 的背景下应用 α2-AR 激动剂后,在离体的成年大鼠心脏中观察到冠状动脉血流的负动力学(38%;p<0.05)。
更新日期:2020-09-01
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