The goal of the research was to show the limits within which Pr3+ can be used as a linear response probe. Temperature dependencies of lanthanide-induced chemical shifts (LISs) were studied using the examples of different phospholipids (POPC, DPPC and the mixture DPPC+DOPC) by means of NMR spectroscopy. It was demonstrated that these dependencies are strongly influenced by the lipid composition and features of temperature dependencies indicate the features in the thermal changes of the structure of liposomes. Features of the temperature dependencies were detected for DPPC and the mixture DPPC+DOPC. The width of these features corresponds to the width of the phase transitions. The analysis of paramagnetic properties such as the temperature sensitivity of LIS indicates the prospect of using kinetically unstable lanthanide complexes as shifting temperature-sensitive probes for determining local temperature and prospective diagnosing diseases using MRI technologies. In the long term, nonlinear changes in the LIS in the inflection region can be useful for practical use (to obtain a very sensitive temperature response, similar to classical titration, when a sharp change close to equivalence makes the measurement sensitive).

中文翻译：

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lipid与脂质的复合物作为NMR温度传感器和脂质体状态的探针

该研究的目的是显示Pr3 +可用作线性响应探针的极限。通过不同的磷脂（POPC，DPPC和DPPC + DOPC混合物）的例子，通过NMR光谱研究了镧系元素诱导的化学位移（LIS）的温度依赖性。已经证明，这些依赖性强烈地受脂质组成的影响，并且温度依赖性的特征表明脂质体结构的热变化的特征。检测了DPPC和DPPC + DOPC混合物的温度依赖性特征。这些特征的宽度对应于相变的宽度。对LIS等顺磁特性的分析表明，使用动力学不稳定的镧系元素络合物作为移动热敏探针来确定局部温度和使用MRI技术进行前瞻性诊断疾病的前景。从长远来看，拐点区域LIS中的非线性变化可能对实际应用有用（当接近当量的急剧变化使测量变得敏感时，获得与经典滴定类似的非常敏感的温度响应）。