Coronavirus disease-19 (COVID-19) continues to be a health threat worldwide. Increased blood lactate is common in intensive care unit (ICU) patients; however, its association with outcomes in ICU COVID-19 patients remains currently unexplored. In this retrospective, observational study we assessed whether lactate is associated with outcomes in COVID-19 patients. Blood lactate was measured on ICU admission and thereafter daily up to day 14 in 45 patients with confirmed COVID-19 pneumonia. Acute physiology and chronic health evaluation (APACHE II) was calculated on ICU admission, and sequential organ failure assessment (SOFA) score was assessed on admission and every second day. The cohort was divided into survivors and non-survivors based on 28-day ICU mortality (24.4%). Cox regression analysis revealed that maximum lactate on admission was independently related to 28-day ICU mortality with time in the presence of APACHE II (RR = 2.45, p = 0.008). Lactate’s area under the curve for detecting 28-day ICU mortality was 0.77 (p = 0.008). Mixed model analysis showed that mean daily lactate levels were higher in non-survivors (p < 0.0001); the model applied on SOFA scores showed a similar time pattern. Thus, initial blood lactate was an independent outcome predictor in COVID-19 ICU patients. The time course of lactate mirrors organ dysfunction and is associated with poor clinical outcomes.

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乳酸动力学反映器官功能障碍，并与重症监护病房COVID-19肺炎患者的不良结果相关：GREEK单中心研究的初步结果

冠状病毒病19（COVID-19）仍然是全球健康威胁。重症监护病房（ICU）患者的血乳酸增加是常见的。然而，其与ICU COVID-19患者预后的关系目前尚待探索。在这项回顾性观察研究中，我们评估了乳酸是否与COVID-19患者的预后相关。在45例确诊为COVID-19肺炎的患者中，在ICU入院后及其后每天进行血乳酸测定，直至第14天。在ICU入院时计算急性生理和慢性健康评估（APACHE II），在入院时和第二天评估序贯器官衰竭评估（SOFA）评分。根据ICU 28天死亡率（24.4％）将队列分为幸存者和非幸存者。p = 0.008）。用于检测28天ICU死亡率的曲线下的乳酸盐面积为0.77（p = 0.008）。混合模型分析显示，非幸存者的平均每日乳酸水平更高（p <0.0001）；在SOFA评分上应用的模型显示了相似的时间模式。因此，初始血乳酸是COVID-19 ICU患者的独立预后指标。乳酸的时程反映出器官功能障碍，并与不良的临床结果相关。