In the basal ganglia (BG), anatomically segregated and topographically organized feedforward circuits are thought to modulate multiple behaviors in parallel. Although topographically arranged BG circuits have been described, the extent to which these relationships are maintained across the BG output nuclei and in downstream targets is unclear. Here, using focal trans-synaptic anterograde tracing, we show that the motor-action-related topographical organization of the striatum is preserved in all BG output nuclei. The topography is also maintained downstream of the BG and in multiple parallel closed loops that provide striatal input. Furthermore, focal activation of two distinct striatal regions induces either licking or turning, consistent with their respective anatomical targets of projection outside of the BG. Our results confirm the parallel model of BG function and suggest that the integration and competition of information relating to different behavior occur largely outside of the BG.

在基底神经节 (BG) 中，解剖学上分离和地形组织的前馈电路被认为可以并行调节多种行为。尽管已经描述了拓扑排列的 BG 电路，但这些关系在 BG 输出核和下游目标中保持的程度尚不清楚。在这里，使用焦点反-突触顺行追踪，我们表明纹状体的运动动作相关的地形组织保留在所有 BG 输出核中。地形也保持在 BG 的下游和提供纹状体输入的多个平行闭环中。此外，两个不同纹状体区域的焦点激活会导致舔或转动，这与它们各自在 BG 外投射的解剖目标一致。我们的结果证实了 BG 功能的并行模型，并表明与不同行为相关的信息的整合和竞争主要发生在 BG 之外。