Reliable functions of bioelectronic devices require conformal, stable and conductive interfaces with biological tissues. Integrating bioelectronic devices with tissues usually relies on physical attachment or surgical suturing; however, these methods face challenges such as non-conformal contact, unstable fixation, tissue damage, and/or scar formation. Here, we report an electrical bioadhesive (e-bioadhesive) interface, based on a thin layer of a graphene nanocomposite, that can provide rapid (adhesion formation within 5 s), robust (interfacial toughness >400 J m⁻²) and on-demand detachable integration of bioelectronic devices on diverse wet dynamic tissues. The electrical conductivity (>2.6 S m⁻¹) of the e-bioadhesive interface further allows bidirectional bioelectronic communications. We demonstrate biocompatibility, applicability, mechanical and electrical stability, and recording and stimulation functionalities of the e-bioadhesive interface based on ex vivo porcine and in vivo rat models. These findings offer a promising strategy to improve tissue–device integration and enhance the performance of biointegrated electronic devices.

生物电子设备的可靠功能需要与生物组织保持一致，稳定和导电的界面。生物电子设备与组织的整合通常依赖于物理附着或手术缝合。然而，这些方法面临诸如非适形接触，固定不稳定，组织损伤和/或疤痕形成的挑战。在这里，我们报告了一种基于石墨烯纳米复合材料薄层的电生物胶粘剂（电子生物胶粘剂）界面，该界面可以提供快速（5 s内形成粘着力），坚固（界面韧性> 400 J m ^-2）和上-要求生物电子设备可拆卸地集成在各种湿动态组织上。电导率（> 2.6 S m ^-1电子生物粘附界面的）还允许双向生物电子通信。我们展示了基于离体猪和体内大鼠模型的电子生物粘附界面的生物相容性，适用性，机械和电稳定性以及记录和刺激功能。这些发现为改善组织-设备集成和增强生物集成电子设备的性能提供了一种有前途的策略。