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The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism
Nature Genetics ( IF 30.8 ) Pub Date : 2020-09-28 , DOI: 10.1038/s41588-020-0694-2
Kwondo Kim 1, 2 , Taehyung Kwon 1 , Tadelle Dessie 3 , DongAhn Yoo 4 , Okeyo Ally Mwai 5 , Jisung Jang 4 , Samsun Sung 2 , SaetByeol Lee 2 , Bashir Salim 6 , Jaehoon Jung 1 , Heesu Jeong 4 , Getinet Mekuriaw Tarekegn 7, 8 , Abdulfatai Tijjani 3, 9 , Dajeong Lim 10 , Seoae Cho 2 , Sung Jong Oh 11 , Hak-Kyo Lee 12 , Jaemin Kim 13 , Choongwon Jeong 14 , Stephen Kemp 5, 9 , Olivier Hanotte 3, 9, 15 , Heebal Kim 1, 2, 4
Affiliation  

Cattle pastoralism plays a central role in human livelihood in Africa. However, the genetic history of its success remains unknown. Here, through whole-genome sequence analysis of 172 indigenous African cattle from 16 breeds representative of the main cattle groups, we identify a major taurine × indicine cattle admixture event dated to circa 750–1,050 yr ago, which has shaped the genome of today’s cattle in the Horn of Africa. We identify 16 loci linked to African environmental adaptations across crossbred animals showing an excess of taurine or indicine ancestry. These include immune-, heat-tolerance- and reproduction-related genes. Moreover, we identify one highly divergent locus in African taurine cattle, which is putatively linked to trypanotolerance and present in crossbred cattle living in trypanosomosis-infested areas. Our findings indicate that a combination of past taurine and recent indicine admixture-derived genetic resources is at the root of the present success of African pastoralism.



中文翻译:

非洲土著牛的马赛克基因组作为非洲畜牧业的独特遗传资源

畜牧业在非洲的人类生计中发挥着核心作用。然而,其成功的遗传历史仍然未知。在这里,通过对代表主要牛群的 16 个品种的 172 头非洲本土牛进行全基因组序列分析,我们确定了大约 750 至 1,050 年前的主要牛磺酸×印度牛混合事件,它塑造了今天牛的基因组在非洲之角。我们确定了 16 个与杂交动物的非洲环境适应相关的基因座,显示出过多的牛磺酸或 indicine 血统。这些包括免疫、耐热和生殖相关基因。此外,我们在非洲牛磺酸中发现了一个高度不同的基因座,该基因座假定与锥虫耐受性有关,并且存在于生活在锥虫病感染地区的杂交牛中。

更新日期:2020-09-28
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