Sirtuins are highly conserved enzymes with key roles in life extension in multiple organisms. A study now describes selective autophagic degradation of nuclear SIRT1 in senescent cells. These observations suggest that blocking sirtuin degradation could be a potential approach for anti-ageing therapies.

中文翻译：

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自噬进入核

Sirtuins 是高度保守的酶，在多种生物的寿命延长中具有关键作用。一项研究现在描述了衰老细胞中核 SIRT1 的选择性自噬降解。这些观察结果表明，阻断sirtuin降解可能是抗衰老疗法的一种潜在方法。