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Cell dormancy plasticity: quiescence deepens into senescence through a dimmer switch
Physiological Genomics ( IF 4.6 ) Pub Date : 2020-09-28 , DOI: 10.1152/physiolgenomics.00068.2020
Kotaro Fujimaki 1 , Guang Yao 1, 2
Affiliation  

Both being dormant cellular states, quiescence and senescence are traditionally considered distinct. Quiescence is reversible to proliferation upon growth signals, whereas senescence is irreversible in physiological conditions. Recent findings, however, suggest that quiescence deepening with a decreased proliferative tendency, but not capability, is a common transition path toward senescence in many cell and tissue types. This transition is associated with the continuously increased activation threshold of an RB-E2F-CDK gene network switch.

中文翻译:

细胞休眠可塑性:静止通过调光开关加深为衰老

静止和衰老都是休眠的细胞状态,传统上被认为是不同的。静止对于生长信号的增殖是可逆的,而衰老在生理条件下是不可逆的。然而,最近的研究结果表明,在许多细胞和组织类型中,随着增殖趋势而非能力的降低,静止加深是衰老的常见过渡途径。这种转变与 RB-E2F-CDK 基因网络开关的激活阈值不断增加有关。
更新日期:2020-09-28
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