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Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity [Psychological and Cognitive Sciences]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-10-13 , DOI: 10.1073/pnas.1922273117
Matilde M Vaghi 1, 2 , Michael Moutoussis 2, 3 , František Váša 4, 5 , Rogier A Kievit 3, 6 , Tobias U Hauser 2, 3 , Petra E Vértes 4, 7, 8 , Nitzan Shahar 2, 3 , Rafael Romero-Garcia 4 , Manfred G Kitzbichler 4 , Edward T Bullmore 4 , , Raymond J Dolan 2, 3
Affiliation  

A characteristic of adaptive behavior is its goal-directed nature. An ability to act in a goal-directed manner is progressively refined during development, but this refinement can be impacted by the emergence of psychiatric disorders. Disorders of compulsivity have been framed computationally as a deficit in model-based control, and have been linked also to abnormal frontostriatal connectivity. However, the developmental trajectory of model-based control, including an interplay between its maturation and an emergence of compulsivity, has not been characterized. Availing of a large sample of healthy adolescents (n = 569) aged 14 to 24 y, we show behaviorally that over the course of adolescence there is a within-person increase in model-based control, and this is more pronounced in younger participants. Using a bivariate latent change score model, we provide evidence that the presence of higher compulsivity traits is associated with an atypical profile of this developmental maturation in model-based control. Resting-state fMRI data from a subset of the behaviorally assessed subjects (n = 230) revealed that compulsivity is associated with a less pronounced change of within-subject developmental remodeling of functional connectivity, specifically between the striatum and a frontoparietal network. Thus, in an otherwise clinically healthy population sample, in early development, individual differences in compulsivity are linked to the developmental trajectory of model-based control and a remodeling of frontostriatal connectivity.



中文翻译:

强迫症与目标导向控制和前纹状体功能连接的青少年发育减少有关[心理和认知科学]

适应性行为的一个特征是其目标导向的性质。以目标导向的方式行动的能力在发展过程中逐渐完善,但这种完善可能会受到精神疾病出现的影响。强迫症在计算上被认为是基于模型的控制的缺陷,并且还与异常的前纹状体连通性有关。然而,基于模型的控制的发展轨迹,包括其成熟与强迫症出现之间的相互作用,尚未得到表征。利用大量健康青少年样本(n= 569) 年龄在 14 到 24 岁之间,我们在行为上表明,在青春期,基于模型的控制在人体内有所增加,这在年轻参与者中更为明显。使用双变量潜在变化评分模型,我们提供的证据表明,较高强迫性特征的存在与基于模型的控制中这种发育成熟的非典型特征相关。来自行为评估对象子集的静息状态 fMRI 数据(n= 230) 揭示强迫症与功能连接的受试者内发育重塑的不太明显的变化有关,特别是在纹状体和额顶叶网络之间。因此,在其他临床健康的人群样本中,在早期发育中,强迫症的个体差异与基于模型的控制的发展轨迹和前纹状体连接的重塑有关。

更新日期:2020-10-13
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