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Release of warfarin from Human Serum Albumin by water-soluble CdSe nanotetrapods.
ChemPhysChem ( IF 2.9 ) Pub Date : 2020-09-28 , DOI: 10.1002/cphc.202000292
Sucheta Banerjee 1 , Tanuja Kistwal 1 , Amritha Sajeevan 2 , Anindya Datta 1
Affiliation  

Water soluble CdSe nanotetrapods are prepared by ligand exchange from organic‐soluble ones. In order to achieve this, oleic acid, which is the capping agent for as prepared water‐insoluble nanotetrapods, is exchanged with mercaptopropanoic acid (MPA). Shape and size of nanotetrapods are conserved upon ligand exchange. Ground state bleach recovery dynamics remain the same as well. However, they are completely non‐emissive. These water‐soluble nanotetrapods disrupt the secondary structure of Human Serum Albumin (HSA) and consequently, release warfarin bound to the protein.

中文翻译:

水溶性CdSe纳米四足动物从人血清白蛋白释放华法林。

水溶性CdSe纳米四足动物是通过有机溶解的配体交换而制备的。为了实现这一目标,油酸是巯基丙酸(MPA)的交换剂,它是制备的水不溶性纳米四足动物的加帽剂。纳米四脚架的形状和大小在配体交换后得以保留。基态漂白剂的恢复动力学也保持不变。但是,它们完全是非发射性的。这些水溶性纳米四足动物破坏了人血清白蛋白(HSA)的二级结构,因此释放了与该蛋白结合的华法林。
更新日期:2020-09-28
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