Abstract Purpose Benzodiazepines (BZDs) are a mainstay of treatment of catatonia with response rates of 60 to 80%, but there is virtually no data regarding the relative efficacy of different agents. We report a patient with catatonia who responded incompletely to lorazepam but much more definitively to clonazepam. Procedures Single case report. Findings A 74 year old man with recurrent catatonia had responded only partially to lorazepam and to a number of other interventions. He was ultimately treated with clonazepam monotherapy and exhibited a much more robust response. Conclusions In this patient, clonazepam may have proved more effective than lorazepam due to its higher affinity for the BZD binding site of the GABAA receptor or possibly due to its longer half life or intrinsic serotonergic activity. It may be reasonable to consider clonazepam in a patient whose response to other BZDs has been incomplete, but this remains to be confirmed in controlled studies.

中文翻译：

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氯硝西泮治疗紧张症对劳拉西泮不完全反应

摘要 目的苯二氮卓类药物 (BZD) 是治疗紧张症的主要药物，反应率为 60% 至 80%，但实际上没有关于不同药物的相对疗效的数据。我们报告了一名紧张症患者，他对劳拉西泮反应不完全，但对氯硝西泮反应更明确。程序 单一病例报告。结果 一名患有反复紧张症的 74 岁男性仅对劳拉西泮和许多其他干预措施有部分反应。他最终接受了氯硝西泮单药治疗，并表现出更加强烈的反应。结论 在该患者中，氯硝西泮可能被证明比劳拉西泮更有效，因为它对 GABAA 受体的 BZD 结合位点具有更高的亲和力，或者可能是由于其更长的半衰期或内在的血清素能活性。