Hypospadias repair involves correcting urethra defects and improving the wound healing process. Zinc has been well accepted as an effective agent in wound healing. This study aimed to investigate the effect of zinc on corpus spongiosum after experimental hypospadias in rats. The animals were divided into three groups. The control group rats underwent general anesthesia, but did not receive any surgeries and treatments. The second and third groups underwent surgeries and respectively received Distilled Water (DW, 2 ml) and zinc sulfate solution (2 ml, containing 4 mg zinc sulfate) by gavages twice a day for 14 days. Stereological methods were used to quantify the corpus spongiosum tissue. The volumes of corpus spongiosum, spongy tissue, urethral lumens, urethral epithelium, and collagen bundles and the number of fibroblasts were respectively amplified by 28%, 40%, 36%, 48%, 40%, and 29% in the surgery + zinc sulfate group in comparison to the surgery + DW group (p < 0.02). It can be concluded that consumption of 4 mg/day zinc sulfate for 14 days could improve the healing of hypospadias through increasing the population of fibroblasts, producing collagen bundles, and building a wider lumen and more epithelized urethra.

中文翻译：

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硫酸锌对大鼠尿道下裂修复术后阴茎海绵体的影响：体视学研究

尿道下裂修复包括纠正尿道缺陷和改善伤口愈合过程。锌已被广泛接受为伤口愈合的有效剂。本研究旨在研究锌对大鼠实验性尿道下裂后海绵体的影响。将动物分成三组。对照组大鼠进行全身麻醉，但不接受任何手术和治疗。第二组和第三组进行手术，分别给予蒸馏水（DW，2ml）和硫酸锌溶液（2ml，含4mg硫酸锌），每天2次，连续14天。体视学方法用于量化海绵体组织。海绵体、海绵组织、尿道管腔、尿道上皮的体积，与手术 + DW 组相比，手术 + 硫酸锌组的胶原束和成纤维细胞数量分别增加了 28%、40%、36%、48%、40% 和 29%（p < 0.02） . 可以得出结论，连续 14 天服用 4 毫克/天的硫酸锌可以通过增加成纤维细胞的数量、产生胶原束以及建立更宽的管腔和更多的上皮化尿道来改善尿道下裂的愈合。