Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying the expression and virally-mediated activation of MDA5. O-GlcNAcylation of MAVS, a down-stream target of MDA5, renders it more effective for type 1 interferon induction. High-dose glucosamine administration up-regulates O-GlcNAcylation by increasing the cellular pool of UDP-N-acetylglucosamine. Hence, it is proposed that joint administration of azithromycin and high-dose glucosamine, early in the course of RNA virus infections, may interact in a complementary fashion to aid their control by enhancing type 1 interferon induction

先前的研究表明，在临床相关浓度下，阿奇霉素可以通过放大 MDA5 的表达和病毒介导的激活来增强 RNA 病毒诱导 1 型干扰素的能力。MAVS 的 O-GlcNAcylation 是 MDA5 的下游靶标，使其对 1 型干扰素诱导更有效。高剂量氨基葡萄糖给药通过增加 UDP -N-乙酰氨基葡萄糖的细胞库上调 O-GlcNAcylation 。因此，建议在 RNA 病毒感染过程的早期联合施用阿奇霉素和高剂量氨基葡萄糖，可能以互补的方式相互作用，通过增强 1 型干扰素诱导来帮助控制它们