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Effects of low levels of the antibiotic ciprofloxacin on the polychaete Hediste diversicolor: biochemical and behavioural effects
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-09-28 , DOI: 10.1016/j.etap.2020.103505
Ana Filipa Nogueira , Bruno Nunes

The release of pharmaceutical chemicals in the biosphere can have unpredictable ecological consequences, and knowledge concerning their putative toxic effects is still scarce. One example of a widely used pharmaceutical that is present in the aquatic environment is ciprofloxacin. Previous indications suggest that this drug may exert several adverse effects on exposed biota, but the characterization of a full ecotoxicological response to this drug is far from complete, especially in estuarine ecosystems. This work aimed to characterize the acute and chronic effects of ciprofloxacin in the polychaete Hediste diversicolor (Annelida: Polychaeta), exposed to environmentally relevant levels of this drug, close to the real concentrations of this pharmaceutical in surface waters. The adopted toxic endpoints were behavioral parameters, combined with a biomarker-based approach (quantification of the activities of catalase (CAT), glutathione-S-transferase (GSTs), cholinesterases (ChEs), glutathione peroxidase (GPx), and lipid peroxidation levels. Exposure to ciprofloxacin caused effects on behavioural traits, such as an increase in burrowing times and hyperactivity, alongside alterations in biomarkers, including a significant increase in CAT activity following acute exposure. In addition, and after both acute and chronic exposure, lipid peroxidation was reduced, while AChE activities were enhanced. It was possible to ascertain the occurrence of pro-oxidative alterations following exposure to low levels of ciprofloxacin, which were counteracted by the triggering of CAT activity. The meaning of the enhancement of AChE activity is not clear, but it appears to be linked with the observed behavioural changes, and may have been associated with the stimulation of the behavioural traits. These data strongly suggest that the presence of ciprofloxacin in estuarine areas is not without risks, and exposed biota, namely polychaete species, are likely to have their ecological roles affected, thereby compromising the chemical, physical and microbiological stability of sediments, which in turn alters nutrient cycles.



中文翻译:

低水平的环丙沙星抗生素对杂色猪形嗜血杆菌的生化和行为影响

药物在生物圈中的释放可能会带来不可预知的生态后果,关于其假定的毒性作用的知识仍然匮乏。存在于水生环境中的一种广泛使用的药物的例子是环丙沙星。先前的迹象表明,该药物可能会对裸露的生物区系产生一些不利影响,但是对该药物的完整生态毒理反应的表征远未完成,特别是在河口生态系统中。这项工作旨在表征环丙沙星在杂色花dist中的急性和慢性作用(Annelida:Polychaeta),暴露于该药物与环境有关的水平,接近该药物在地表水中的实际浓度。采用的毒性终点是行为参数,结合了基于生物标志物的方法(量化过氧化氢酶(CAT),谷胱甘肽S-转移酶(GST),胆碱酯酶(ChEs),谷胱甘肽过氧化物酶(GPx)和脂质过氧化水平的活性暴露于环丙沙星会导致行为特征受到影响,例如钻洞时间和活动过度,以及生物标志物的变化,包括急性暴露后CAT活性显着增加;此外,急性和慢性暴露后,脂质过氧化减少了AChE的活动。可以确定暴露于低水平的环丙沙星后促氧化变化的发生,这可以通过触发CAT活性来抵消。AChE活性增强的含义尚不清楚,但似乎与观察到的行为变化有关,并且可能与行为特征的刺激有关。这些数据强烈表明环丙沙星在河口地区的存在并非没有风险,裸露的生物区(即多毛类)很可能会影响其生态作用,从而损害沉积物的化学,物理和微生物稳定性,进而改变沉积物的化学,物理和微生物稳定性。营养循环。AChE活性增强的含义尚不清楚,但似乎与观察到的行为变化有关,并且可能与行为特征的刺激有关。这些数据强烈表明环丙沙星在河口地区的存在并非没有风险,裸露的生物区(即多毛类)很可能会影响其生态作用,从而损害沉积物的化学,物理和微生物稳定性,进而改变沉积物的化学,物理和微生物稳定性。营养循环。AChE活性增强的含义尚不清楚,但似乎与观察到的行为变化有关,并且可能与行为特征的刺激有关。这些数据强烈表明环丙沙星在河口地区的存在并非没有风险,裸露的生物区(即多毛类)很可能会影响其生态作用,从而损害沉积物的化学,物理和微生物稳定性,进而改变沉积物的化学,物理和微生物稳定性。营养循环。

更新日期:2020-10-07
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