The DNA damage response enables cells to cope with various stresses that threaten genomic integrity. A critical component of this response is the serine/threonine kinase CHK1 which is encoded by the CHEK1 gene. Originally identified as a regulator of the G2/M checkpoint, CHK1 has since been shown to play important roles in DNA replication, mitotic progression, DNA repair, and overall cell cycle regulation. However, the potential of CHK1 as a cancer therapy has not been realized clinically. Herein we expound our current understanding of the principal roles of CHK1 and highlight different avenues for CHK1 targeting in cancer therapy.

中文翻译：

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现实CHEK：了解CHK1的生物学和临床潜力

DNA损伤反应使细胞能够应对威胁基因组完整性的各种压力。该应答的关键成分是由CHEK1基因编码的丝氨酸/苏氨酸激酶CHK1 。CHK1最初被确定为G2 / M检查点的调节物，自那以后已显示出它在DNA复制，有丝分裂进程，DNA修复和整个细胞周期调节中起重要作用。但是，CHK1作为一种癌症疗法的潜力尚未在临床上实现。在这里，我们阐述了我们对CHK1的主要作用的当前理解，并突出了在癌症治疗中靶向CHK1的不同途径。