Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory bioavailability in the gastrointestinal tract. One of the critical and most overlooked factors is the symbiotic gut microbiota that can modulate the bioavailability of oral drugs by participating in the biotransformation of oral drugs, influencing the drug transport process and altering some gastrointestinal properties. In this review, we summarized the existing research investigating the possible relationship between the gut microbiota and the bioavailability of oral drugs, which may provide great ideas and useful instructions for the design of novel drug delivery systems or the achievement of personalized medicine.

口服给药因其安全、方便、成本低、依从性好而受到广泛关注。然而，许多口服药物的功效受限于其在胃肠道中的生物利用度不理想。关键且最容易被忽视的因素之一是共生肠道微生物群，它可以通过参与口服药物的生物转化、影响药物转运过程和改变一些胃肠特性来调节口服药物的生物利用度。在这篇综述中，我们总结了现有研究肠道菌群与口服药物生物利用度之间可能关系的研究，这可能为新型给药系统的设计或个体化医疗的实现提供很好的思路和有用的指导。